Croatica Chemica Acta

  ☆   published by the Croatian Chemical Society   ☆   est. 1927


Croat. Chem. Acta 71 (1998) 659-672.


Conference Paper

Structural Studies on the Interactions between Metal Ions and Biological Macromolecules

Pierluigi Orioli

Department of Chemistry, University of Florence,
Via Capponi 7, 50121 Florence, Italy

Received February 3, 1998;   revised July 13, 1998;   accepted July 15, 1998

The essential role of metal ions in biology is stressed by structural investigations on two metalloenzymes: human carbonic anhydrase (CA) and Cu, Zn superoxide dismutase (SOD). The X-ray structure of CA complex with histamine affords a satisfactory explanation of the mechanism of activation of CA. The high resolution (1.02 A) crystal structure of a mutant monomeric Cu, Zn superoxide dismutase gives relevant information on the mechanism of the catalytic activity of the native dimeric enzyme and on the reduced activity of the monomer.

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